Small intestine permeable peptides facilitate digestive tract absorption
Orally administered medicines are among the most convenient and safest types of medications . Many drugs currently on the market are low molecular weight compounds that can be absorbed by the small intestine. Bio-medicines such as insulin, antibodies, and nucleic acids have attracted attention in recent years but are almost completely unabsorbed in the small intestine because they are macromolecular compounds with large constituent molecular weights. Therefore, there are currently no oral formulations for these biopharmaceuticals so they are administered through injections, which are physically and mentally burdensome to the patient. Cell-penetrating peptides (CPPs) are peptides that facilitate the delivery of various molecules with low cell membrane permeability, such as proteins or nucleic acids, through the cell membrane. It is therefore attracting attention as a method to facilitate small intestine absorption (penetration) of polymer drugs. However, when using existing CPPs to ...